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Biophysics

Biomolecular Interaction Analysis

The absolute, multi-parameter measurements provided by AnaLight® instruments enable the researcher to explore and understand the structural changes taking place in biomolecules as they function. The affinity and kinetics of interactions can be followed through measurement of mass changes with class-leading sensitivity to small mass binders. Additionally, the mass measured by AnaLight® is quantitative, so can also reveal the stoichiometry of interactions. The structural changes taking place during interactions are measured simultaneously in terms of molecular dimensions and molecular fold density, showing dynamic conformational changes and differentiating between specific and non-specific binding events. The structural nature of macromolecular complexes can be determined through the density measurements before and after interaction. AnaLight® provides insights into biomolecular interactions at a resolution not previously available in a laboratory-based technique.

Application notes are available as PDF documents that can be either downloaded or viewed online:

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For further information, or application discussions, please contact: applications@farfield-group.com

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