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Biophysics

Membrane Protein and Lipid Studies

The structural measurements provided by AnaLight® instruments enable the researcher to understand the macrostructures formed by lipids, such as bilayers and liposomes, and to understand how changes in these structures relate to functional events. The affinity and kinetics of lipid - lipid and protein - lipid interactions can be followed through measurement of mass changes with class-leading sensitivity to small mass binders. The structural changes taking place during interactions are measured simultaneously in terms of molecular dimensions and molecular fold density. The structural nature of protein - lipid complexes can be determined through the dimensional and density measurements, revealing information about insertion versus surface binding. The understanding of lipid structures provided by AnaLight® forms a firm basis for the subsequent study of the structure and function of membrane proteins and their interactions in a biomimetic membrane environment.

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