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Biophysics

Protein - Metal Ion Interactions

The activity of a wide range of biomolecules is mediated and regulated by metal ion binding. The high-resolution, quantitative structural and functional measurements provided by AnaLight® instruments allow the researcher to understand the structural changes taking place in biomolecules when they bind metal ions. The structural changes taking place during these interactions can be measured simultaneously in terms of molecular dimensions and molecular fold density. Differential metal ion binding can be assessed not only by affinity, but also in terms of the structural changes brought about on binding to the target protein. AnaLight® provides the measurements to connect the changes in biomolecular structure on metal ion binding with the subsequent changes in biological activity and function, at a resolution not previously available in a laboratory-based technique.

Application notes are available as PDF documents that can be either downloaded or viewed online:

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For further information, or application discussions, please contact: applications@farfield-group.com

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