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Biophysics

Biomolecular Stability and Structure

Unlike first-generation biosensor technologies, the multi-parameter structural measurements provided by AnaLight® instruments are not dependent on any mass changes taking place in the molecules under investigation. This allows the researcher to explore and understand structural changes in biomolecules brought about by environmental factors such as pH, salt, temperature, solvents and buffers. The correct function of biomolecules is known to be dependent on their structural integrity and stability, and AnaLight® has the unique sensitivity to measure structural changes without mass change. The structural changes taking place are measured simultaneously in terms of molecular dimensions and molecular fold density. AnaLight® provides the measurements to assess changes in biomolecular structure and to explore environmental conditions that either prevent, or cause, these changes at a resolution not previously available in a laboratory-based technique.

Application notes are available as PDF documents that can be either downloaded or viewed online:

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Visit the InfoZone to view a list of published papers and conference posters relevant to this application area.

For further information, or application discussions, please contact: applications@farfield-group.com

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