Conformation Activity Relationship

Farfield's work over the past decade has revolved around the direct measurement of the shape or conformation of biomolecules and how this changes as the biomolecules function. This ability to monitor the Conformation Activity Relationship (CAR) has now matured into a benchtop analytical tool known as a Dual Polarisation Interferometer which measures the molecular size and fold density (and therefore mass as well) of interacting biomolecules captured on a glass slide. The technique has picometer resolution, is real time and label free and already has a growing userbase across 19 countries worldwide.

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Application notes:

• Drug Discovery & Development - Biophysics Applications - Applications
  Drug Discovery and Development: Protein - Small Molecule Interactions The unique combination of quantitative structural and functional measurements provided by AnaLight® instruments allow the researcher to understand the conformational and other structural functions.
• Biomolecular Interaction Analysis - Biophysics Applications - Applications
  Biomolecular Interaction Analysis The absolute, multi-parameter measurements provided by AnaLight® instruments enable the researcher to explore and understand the structural changes taking place in biomolecules as they function.